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ba0001pp255 | Chondrocytes and cartilage | ECTS2013

Effects of an in vitro low-oxygen-tension preconditioning of adipose stem cells on their in vivo chondrogenic potential: application in cartilage tissue repair

Portron Sophie , Merceron Christophe , Gauthier Olivier , Lesoeur Julie , Sourice Sophie , Masson Martial , Fellah Borhane , Geffroy Olivier , Lallemand Elodie , Weiss Pierre , Guicheux Jerome , Vinatier Claire

Purpose: Multipotent stromal cells (MSC)-based regenerative strategy is promising for the repair of cartilage, which is an avascular tissue in which cells experience hypoxia. Hypoxia is known to promote the early chondrogenic differentiation of MSC. Therefore, the aim of our study was to determine whether low oxygen tension could be used to enhance the regenerative potential of MSC for cartilage repair.Methods: MSC from rabbits or human adipose tissues (...

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Effects of an in vitro low-oxygen-tension preconditioning of adipose stem cells on their in vivo chondrogenic potential: application in cartilage tissue repair

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